You can find more information about PF3D7_0603300-dihydroorotate dehydrogenase using the following links:

PlasmoDB - the Plasmodium genome resource
The TDR Targets Database

Subcellular Localization

PDB protein strucure

Affecting Drugs
Drug Name PubMed Articles (year of publication)
(2-(1,1-Difluoroethyl)-5-methyl-N-(6-(trifluoromethyl)pyridin-3-yl)-[1,2,4]triazolo[1,5- a]pyrimidin-7-amine)
(2s)-2-amino-4-azidobutanoic acid
(2S,3S,4S)-2-cyano-3-[4-[2-(3-fluorophenyl)ethynyl]phenyl]-4-(hydroxymethyl)-N-propylazetidine-1-carboxamide
(2S,3S,4S)-2-Cyano-3-{4-[(3-fluorophenyl)ethynyl]phenyl}-4-(hydroxymethyl)-N-propyl-1-azetidinecarboxamide
(5-methyl-4-((6-(trifluoromethyl)pyridin-3-yl)methyl)-1H-pyrrol-2-yl)(pyrrolidin-1-yl)methanone
(E/Z)-ethyl 3- (dibenzothiophen-2’-ylaminomethylene)-2-nitroacrylate
(E/Z)-ethyl 3-(9’-ethyl-9Hcarbazol-3’-ylamino)-2-nitroacrylate
(Z)-2-cyano-3-cyclopropyl-3-hydroxy-N-(4-nitrophenyl)prop-2-enamide
(Z)-2-cyano-3-cyclopropyl-3-hydroxy-N-[4-(trifluoromethyl)phenyl]prop-2-enamide
(Z)-2-cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]but-2-enamide
(Z)-2-cyano-N-(4-cyanophenyl)-3-cyclopropyl-3-hydroxy-prop-2-enamide
[4-[[5-tert-butyl-2-(1,1-difluoroethyl)-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl]amino]phenyl]-(thioxoferrioferrio)iron
[5-(2-isopropoxy-2-oxo-ethoxy)-2-methyl-benzofuran-3-yl] butanoate
1-(4-chlorobenzoyl)-N-((5-(furan-2-yl)-1,3,4-oxadiazol-2-yl)methyl)-N-propylpiperidine-3-carboxamide
1-(4-Chlorophenyl)-1,6-dihydro-6,6-dimethyl-1,3,5-triazine-2,4-diamine
2-(((1-((1,2,3,4-tetrahydroquinolin-4-yl)amino)cyclopentyl)methyl)amino)quinolin-4(1H)-one
2-((1-(3-fluoro-4-methoxyphenyl)-1H-1,2,3-triazol-4-yl)methoxy)naphthalene-1,4-dione
2-(1,1-difluoroethyl)-5-methyl-N-(4-(pentafluoro-l6-sulfaneyl)phenyl)-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
2-(1,1-difluoroethyl)-5-methyl-N-[4-(pentafluoro-$l^{6}-sulfanyl)phenyl]-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
2-(1,1-difluoroethyl)-5-methyl-N-[4-(pentafluoro-lambda6-sulfanyl)phenyl]-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
2-(1,1-Difluoroethyl)-5-methyl-N-[4-(pentafluoro-λ6-sulfanyl)phenyl][1,2,4]triazolo[1,5-a]pyrimidin-7-amine
2-(1,1-difluoroethyl)-5-methyl-N-[4-(pentafluoro-λ6-sulfanyl)phenyl]-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
2-(1,1-difluoroethyl)-5-methyl-N-[5-(trifluoromethyl)-2-pyridyl]-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
2-(1,1-Difluoroethyl)-5-methyl-N-[6-(trifluoromethyl)-3-pyridinyl][1,2,4]triazolo[1,5-a]pyrimidin-7-amine
2-(1,1-difluoroethyl)-N-(4-(1,1-difluoroethyl)phenyl)-5-methyl-7aH-imidazo[4,5-b]pyridin-7-amine
2-(3-methylbut-2-en-1-yl)-3-(2-(1-(pyridin-3-yl)-1H-1,2,3-triazol-4-yl)ethoxy)-2,3-dihydronaphthalene-1,4-dione
2-(trifluoromethyl)[1,2,4]triazolo[1,5-a]pyrimidine
2,5-Dimethyl-7-(2-(trifluoromethyl)phenylamine)-pyrazolo [1,5-a]pyrimidine
2,5-Dimethyl-7-(naphthalen-2-ylamine)pyrazolo [1,5-a]pyrimidine
2-[(6-bromonaphthalene-2-carbonyl)-methyl-amino]benzoic acid
2-[methyl-(4-phenylbenzoyl)amino]benzoic acid
29582555
2-benzamido-1-(3-phenylpropyl)benzimidazole-5-carboxylic acid
2-cyano-3-(9- ethyl-9h-carbazol-3-ylamino)acrylic acid
2-ethyl-N-(4-iodophenyl)-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
33852304
3-Amino-1-(naphthalen-2-yl)-2,3-dihydrofuro[2,3-d]pyrimidine-4,5(1H,6H)-dione
3-Hydroxy-1-methyl-5-((3-(trifluoromethyl)phenoxy)methyl)-1H-pyrazole-4-carboxylic acid
5-(2-methylbenzimidazol-1-yl)-n-alkylthiophene-2-carboxamides
5-(2-methylbenzimidazol-1-yl)-N-propyl-thiophene-2-carboxamide
5-(2-methylindol-1-yl)-N-propyl-thiophene-2-carboxamide
5-(4-Cyano-2-methyl-1H-benzimidazol)-1-yl-N-cyclopropyl-2-thiophenecarboxamide
5-(4-Cyano-2-methyl-1H-benzimidazol-1-yl)-N-cyclopropyl-2-thiophenecarboxamide
5-(4-cyano-2-methyl-benzimidazol-1-yl)-N-cyclopropyl-thiophene-2-carboxamide
5-chloro-N-(1-naphthyl)pyrazolo[1,5-a]pyrimidin-7-amine
5-cyclopropyl-2-(4-(2,6-difluorophenoxy)-3-isopropoxy-5-methyl-1H-pyrazol-1-yl)-3-fluoropyridine
5-fluoroorotate
5-methyl-2-(trifluoromethyl)-N-[4-(trifluoromethyl)phenyl]-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
5-methyl-2-(trifluoromethyl)-N-[5-(trifluoromethyl)-2-pyridyl]-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
5-Methyl-7-(naphthalen-2-ylamine)-2-(trifluoromethyl)pyrazolo [1,5-a]pyrimidine
5-methyl-N-(1-naphthyl)pyrazolo[1,5-a]pyrimidin-7-amine
5-Methyl-N-(2-naphthyl)[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
5-methyl-N-(2-naphthyl)-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
5-Methyl-N-[4-(trifluoromethyl)phenyl][1,2,4]triazolo[1,5-a]pyrimidin-7-amine
6-[1-(2-Fluoro-4-biphenylyl)ethyl]-3-(2-furyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole
6-methoxy-N-pyrazolo[1,5-a]pyrimidin-7-yl-quinolin-8-amine
7-(3,5-Dimethoxyphenylamine)-2-methyl-5-(trifluoromethyl) pyrazolo [1,5-a]pyrimidine
7-methoxy-1-methyl-9H-pyrido[3,4-b]indole
9-(naphthalen-2-yl)-3,4-dihydro-2H,6H-benzo[e]pyrimido[1,2-c][1,3]thiazin-6-imine
A77 1726
Atovaquone
Azktb
Brequinar
Brequinar sodium
Bromonaphthyl
Chembl1738786
Chembl1784577
Chembl1956285
Crystal structure, suggested target
DBP-All255
DBP-Top1
dichloroallyl lawsone
Diethyl 3,4-methylenedioxyphenylaminomethylenemalonate
Different species-selective inhibitors
Dihydrothiophenone
Dsm1
DSM-1
Dsm195
Dsm196
Dsm254
DSM265
Dsm266
Dsm271
Dsm272
Dsm280
Dsm281
Dsm307
Dsm308
Dsm309
Dsm314
Dsm322
Dsm323
Dsm326
Dsm327
Dsm328
Dsm329
Dsm74
Dsm75
Dsm89
dynasore
Elq-300
ethyl (1S*,3S*,5S*)-1,5-dimethyl-7-oxo-3-phenyltetrahydro-1H,5H-pyrazolo[1,2-a]pyrazole-1-carboxylat
Ethyl 2-(3,4-dimethylphenylamino)-4-oxo-4,5-dihydrothiophene-3-carboxylate
Ethyl 2-(4-tert-butylphenylamino)-4-oxo-4,5-dihydrothiophene-3-carboxylate
Ethyl 2-(anthracen-2-ylamino)-4-oxo-4,5-dihydrothiophene-3-carboxylate
Ethyl 2-(naphthalen-2-ylamino)-4-oxo-4,5-dihydrothiophene-3-carboxylate
ethyl 4-(3,3-dimethylbutanoyloxy)-5-hydroxy-2-methyl-benzofuran-3-carboxylate
ethyl 4-[(4-ethoxyphenyl)methyl]-3,5-dimethyl-1H-pyrrole-2-carboxylate
Ethyl 4-oxo-2-(5,6,7,8-tetrahydronaphthalen-2-ylamino)-4,5-dihydrothiophene-3-carboxylate
Fp-3
https://pubchem.ncbi.nlm.nih.gov/compound/19369059
Hydroxamic acid
hypo1
Imidazo[1,2-α]pyrimidines
Inhibitors docked into the ubiquinone-binding pocket of dhodh
Leflunomide
Luteolin
Methyl 1-(2,4,6-Trichlorophenyl)-3-hydroxy-1H-pyrazole-4-carboxylate
Methyl 2-(naphthalen-2-ylamino)-4-oxo-4,5-dihydrothiophene-3-carboxylate
mitorubrinol
MMV011256
MMV011259
MMV665874
N-(2-anthryl)-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
N-(3,4-difluorophenyl)-2-methyl-3-nitrobenzamide
N-(3,5-dichlorophenyl)-2-methyl-3-nitrobenzamide
N-(3,5-dichlorophenyl)-2-methyl-3-nitro-benzamide
N-(3,5-dichloro-phenyl)-2-methyl-3-nitro-benzamide.
N-(3-hydroxyphenyl)-2-methyl-3-nitrobenzamide
N-(4-bromo-2-methylphenyl)-2-naphthamide
N-(4-chlorophenyl)-4-((5-methyl-2-(trifluoromethyl)-[1,2,4]tri-azolo[1,5-a]pyrimidin-7-yl)amino)benzenesulfonamide hydro-chloride
N-[(2S)-7-bromotetralin-2-yl]-2-(1,1-difluoroethyl)-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
N-[2-[(4-benzylpiperazin-1-yl)methyl]-1-ethylbenzimidazol-5-yl]thiophene-2-carboxamide
N-[3-fluoro-4-(trifluoromethyl)phenyl]-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
N1-(7-chloroquinolin-4-yl)-N6-(5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl)hexane-1,6-diamine
N-alkyl-5-(1h-benzimidazol-1-yl)thiophene-2-carboxamides
Naphthamide
N-arylaminomethylene malonates
N-cyclopropyl-4-((2-fluoro-6-(trifluoromethyl)pyridin-3-yl)methyl)-3-methyl-1H-pyrrole-2-carboxamide
N-cyclopropyl-5-(2-methyl-5-(trifluoromethoxy)-1h-benzo[d]imidazol-1-yl)thiophene-2-carboxamide
N-cyclopropyl-5-(4,5,6-trichloro-2-methyl-benzimidazol-1-yl)thiophene-2-carboxamide
N-cyclopropyl-5-(4-fluoro-6-methyl-benzimidazol-1-yl)thiophene-2-carboxamide
N-cyclopropyl-5-[(4-methylphenyl)methylsulfanylmethyl]furan-2-carboxamide
N-cyclopropyl-5-[2-methyl-5-(trifluoromethoxy)benzimidazol-1-yl]thiophene-2-carboxamide
N-cyclopropyl-5-[4-(difluoromethoxy)-2-methyl-benzimidazol-1-yl]thiophene-2-carboxamide
NSC 20535
NSC 24120
NSC336047
P218
Phenyl benzamide
rac-(4S)-2-cyano-4-(hydroxymethyl)-3-[4-[2-(4-phenoxyphenyl)ethynyl]phenyl]-N-propyl-azetidine-1-carboxamide
rac-(4S)-2-cyano-4-(hydroxymethyl)-N-propyl-3-[4-[2-[2-[rac-(1E)-1-methylbuta-1,3-dienyl]-3H-pyrazol-5-yl]ethynyl]phenyl]azetidine-1-carboxamide
rac-(4S)-3-[4-[2-[2,3-bis(trifluoromethyl)phenyl]ethynyl]phenyl]-2-cyano-4-(hydroxymethyl)-N-propyl-azetidine-1-carboxamide
Redoxal
Spiroindolone
Strictosamide
Suggested target
Tcmdc-124418
TCMDC-135546
TCMDC-136129
teriflunomide
Trifluoromenadione
X-ray crystallographic, chembridge database compound
ZINC00386658