You can find more information about PF3D7_0615100-Enoyl-ACP reductase using the following links:

Subcellular Localization

• Picture 1
• Picture 2
• Picture 3

PDB protein strucure

• 1NHG
• 1NHW
• 1VRW
• 1ZSN
• 1NNU
• 1ZW1
• 1ZXL
• 2OL4
• 2OP1
• 2OOS
• 2NQ8
• 3LT4
• 3LSY
• 3LT0
• 3LT1
• 3LT2
• 3AM4
• 1ZXB
• 4IGE
• 4IGF
• 2O2Y
• 3AM3
• 3AM5
• 1V35
• 1UH5

Affecting Drugs
Drug Name	PubMed Articles (year of publication)
(1aR,4aR,6aS,7R,9bR,10S,11S,11aR)-7-(furan-3-yl)-10,11-dihydroxy-1a,4a,6a,9b-tetramethyl-4a,4b,5,6,6a,7,8,9b,10,11-decahydrocyclopenta[7,8]phenanthro[1,10a-b]oxiren-4(1aH)-one	Structure-Based Design and Pharmacophore-Based Virtual Screening of Combinatorial Library of Triclosan Analogues Active against Enoyl-Acyl Carrier Protein Reductase of Plasmodium falciparum with Favourable ADME Profiles(2023)
(1R,3S,5R,6S)-6-Hydroxy-3-{[(2S)-3-hydroxy-2-phenylpropanoyl]oxy}-8-methyl-8-azoniabicyclo[3.2.1]octane	Identification of novel antiplasmodial compound by hierarquical virtual screening and in vitro assays(2020)
(E)-2,3-dihydroxypiperidine-4-carbohydrazonoyl iodide	Drug-likeness prediction of designed analogues of isoniazid standard targeting FabI enzyme regulation from P. falciparum(2019)
(e)-oroidin	Marine natural products from the Turkish sponge Agelas oroides that inhibit the enoyl reductases from Plasmodium falciparum, Mycobacterium tuberculosis and Escherichia coli(2007)
[(3aR,4S,6aR)-5-(hydroxymethyl)-3,3a,4,6a-tetrahydro-2H-cyclopenta[b]furan-4-yl]methanol	Anti-protozoal and plasmodial FabI enzyme inhibiting metabolites of Scrophularia lepidota roots(2005)
[4-(9H-fluoren-9-yl)piperazin-1-yl]-(1H-indol-5-yl)methanone	Targeting tuberculosis and malaria through inhibition of Enoyl reductase: compound activity and structural data(2003)
1-[3-chloro-4-(4-chloro-2-hydroxy-phenoxy)phenyl]propane-1,2-dione	Molecular modeling studies, synthesis, and biological evaluation of Plasmodium falciparum enoyl-acyl carrier protein reductase (PfENR) inhibitors(2009)
15-Desoxyspergualin	15-Deoxyspergualin hinders physical interaction between basic residues of transit peptide in PfENR and Hsp70-1(2012)
1-benzyl-3-acetyl-1,4-dihydropyridine	Structural elucidation of the specificity of the antibacterial agent triclosan for malarial enoyl acyl carrier protein reductase(2002)
1-benzyl-3-carbamoyl-1,4-dihydropyridine	Structural elucidation of the specificity of the antibacterial agent triclosan for malarial enoyl acyl carrier protein reductase(2002)
1-benzyl-3-carboxymethoxy-1,4-dihydropyridine	Structural elucidation of the specificity of the antibacterial agent triclosan for malarial enoyl acyl carrier protein reductase(2002)
1-benzyl-3-thiocarbamoyl-1,4-dihydropyridine	Structural elucidation of the specificity of the antibacterial agent triclosan for malarial enoyl acyl carrier protein reductase(2002)
2-(2,4-dichlorophenoxy)-5-(2-phenylethyl)phenol	Design and in silico screening of combinatorial library of antimalarial analogs of triclosan inhibiting Plasmodium falciparum enoyl-acyl carrier protein reductase(2009)
2-(2'-amino-4'-chloro-phenoxy)-5-chloro-phenol, 5-chloro-2-(4'-chloro-2'-nitro-phenoxy)-phenol)	Design, development, synthesis, and docking analysis of 2'-substituted triclosan analogs as inhibitors for Plasmodium falciparum enoyl-ACP reductase(2009)
2-(2-hydrazinyl)thiazole	In vitro and in silico antimalarial activity of 2-(2-hydrazinyl)thiazole derivatives(2014)
2,2'-dihydroxydiphenyl ether	Kinetic determinants of the interaction of enoyl-ACP reductase from Plasmodium falciparum with its substrates and inhibitors(2001)
2-[2-[(1,4,4a,8a-tetrahydronaphthalen-1-ylamino)methyl]phenoxy]-5-chloro-phenol	Synthesis and biological activity of diaryl ether inhibitors of malarial enoyl acyl carrier protein reductase. Part 2: 2'-substituted triclosan derivatives(2006)
2-[3-chloro-4-(4-chloro-2-hydroxy-phenoxy)phenyl]acetonitrile	Molecular modeling studies, synthesis, and biological evaluation of Plasmodium falciparum enoyl-acyl carrier protein reductase (PfENR) inhibitors(2009)
2-[4-(2,4-dinitrophenyl)pyrazol-1-yl]-4-(trifluoromethyl)pyrimidine	Targeting tuberculosis and malaria through inhibition of Enoyl reductase: compound activity and structural data(2003)
24-ethyl-cholest- 5a-7-en-3-b-ol	Marine natural products from the Turkish sponge Agelas oroides that inhibit the enoyl reductases from Plasmodium falciparum, Mycobacterium tuberculosis and Escherichia coli(2007)
2-octadecynoic acid	2-Octadecynoic acid as a dual life stage inhibitor of Plasmodium infections and plasmodial FAS-II enzymes(2014)
2-thioxothiazolidin-4-one	Discovery of a rhodanine class of compounds as inhibitors of Plasmodium falciparum enoyl-acyl carrier protein reductase(2007)
3,4-dihydro-methylcatalpol	Anti-protozoal and plasmodial FabI enzyme inhibiting metabolites of Scrophularia lepidota roots(2005)
3,7dihydroxyflavone	Compound prioritization from inverse docking experiment using receptor-centric and ligand-centric methods: a case study on Plasmodium falciparum Fab enzymes(2014)
3-amino-1-(2-aminoimidazoyl)-prop-1-ene	Marine natural products from the Turkish sponge Agelas oroides that inhibit the enoyl reductases from Plasmodium falciparum, Mycobacterium tuberculosis and Escherichia coli(2007)
3-Bromo-N-(4-fluorobenzyl)-benzo[b]thiophene-2-carboxamide	Benzothiophene carboxamide derivatives as inhibitors of Plasmodium falciparum enoyl-ACP reductase(2011)
3-Bromo-N-[4-(trifluoromethyl)benzyl]-benzo[b]thiophene-2-carboxamide	Benzothiophene carboxamide derivatives as inhibitors of Plasmodium falciparum enoyl-ACP reductase(2011)
4,5-dibromopyrrole-2-carboxylic acid	Marine natural products from the Turkish sponge Agelas oroides that inhibit the enoyl reductases from Plasmodium falciparum, Mycobacterium tuberculosis and Escherichia coli(2007)
4-bromo-N-[3-(trifluoromethyl)phenyl]benzamide	Discovery of novel inhibitors targeting enoyl-acyl carrier protein reductase in Plasmodium falciparum by structure-based virtual screening(2007)
5',4'-dihydroxy-6,7-dimethoxy-flavanone	Integrated ligand and structure based studies of flavonoids as fatty acid biosynthesis inhibitors of Plasmodium falciparum(2010)
5-chloro-2-(2-chloro-4-nitro-phenoxy)phenol	Molecular modeling studies, synthesis, and biological evaluation of Plasmodium falciparum enoyl-acyl carrier protein reductase (PfENR) inhibitors(2009)
5-chloro-2-[2-[(2-cyclohexa-2,4-dien-1-ylethylamino)methyl]phenoxy]phenol	Synthesis and biological activity of diaryl ether inhibitors of malarial enoyl acyl carrier protein reductase. Part 2: 2'-substituted triclosan derivatives(2006)
5-chloro-2-[2-[(cyclohexa-2,4-dien-1-ylmethylamino)methyl]phenoxy]phenol	Synthesis and biological activity of diaryl ether inhibitors of malarial enoyl acyl carrier protein reductase. Part 2: 2'-substituted triclosan derivatives(2006)
5-chloro-2-[4-chloro-2-[(cyclohexa-2,4-dien-1-ylmethylamino)methyl]phenoxy]phenol	Synthesis and biological activity of diaryl ether inhibitors of malarial enoyl acyl carrier protein reductase. Part 2: 2'-substituted triclosan derivatives(2006)
5-chloro-2-[4-chloro-2-[[(3-chlorophenyl)methylamino]methyl]phenoxy]phenol	Synthesis and biological activity of diaryl ether inhibitors of malarial enoyl acyl carrier protein reductase. Part 2: 2'-substituted triclosan derivatives(2006)
5-chloro-2-[4-chloro-2-[1-[(3-chlorophenyl)methylamino]-1-methyl-ethyl]phenoxy]phenol	Synthesis and biological activity of diaryl ether inhibitors of malarial enoyl acyl carrier protein reductase. Part 2: 2'-substituted triclosan derivatives(2006)
5-hexadecynoic	2-Hexadecynoic acid inhibits plasmodial FAS-II enzymes and arrests erythrocytic and liver stage Plasmodium infections(2010)
6-hexadecynoic	2-Hexadecynoic acid inhibits plasmodial FAS-II enzymes and arrests erythrocytic and liver stage Plasmodium infections(2010)
6-hydroxy-flavone	Integrated ligand and structure based studies of flavonoids as fatty acid biosynthesis inhibitors of Plasmodium falciparum(2010)
7-[2-(4-Methoxyphenyl)-2-oxoethoxy]-3,4,8-trimethyl-2H-chromen-2-one	A novel antiplasmodial compound: integration of in silico and in vitro assays(2021)
9-hexadecynoic	2-Hexadecynoic acid inhibits plasmodial FAS-II enzymes and arrests erythrocytic and liver stage Plasmodium infections(2010)
Aclarubicin	Celastrol inhibits Plasmodium falciparum enoyl-acyl carrier protein reductase(2014)
Antibodies and small molecules	In silico screening for Plasmodium falciparum enoyl-ACP reductase inhibitors(2015)
Apigenin	Compound prioritization from inverse docking experiment using receptor-centric and ligand-centric methods: a case study on Plasmodium falciparum Fab enzymes(2014)
Artemisia afra extract	Expression of the Fab enzymes (Fab I and Fab Z) from Plasmodium falciparum after exposure to Artemisia afra plant extracts and drugs screening(2023)
Aryloxyalkylbenzamide	Novel type II fatty acid biosynthesis (FAS II) inhibitors as multistage antimalarial agents(2013)
Benzodiazaborine	Inhibitors of FabI, an enzyme drug target in the bacterial fatty acid biosynthesis pathway(2008)
Casticin	Antiprotozoal Effect of Artemisia indica Extracts and Essential Oil(2015)
Catechin gallate	Integrated ligand and structure based studies of flavonoids as fatty acid biosynthesis inhibitors of Plasmodium falciparum(2010)
Cerulenin	Mass spectrometry-based systems approach for identification of inhibitors of Plasmodium falciparum fatty acid synthase(2007)
Chcl(3) extract of rhododendron ungernii leaves, h(2)o-soluble portion of rhododendron smirnovii leaves	Evaluation of antiprotozoal and plasmodial enoyl-ACP reductase inhibition potential of turkish medicinal plants(2005)
Chembridge express library	Discovery of novel inhibitors targeting enoyl-acyl carrier protein reductase in Plasmodium falciparum by structure-based virtual screening(2007)
Chrysoplenetin	Antiprotozoal Effect of Artemisia indica Extracts and Essential Oil(2015)
Cirsilineol	Antiprotozoal Effect of Artemisia indica Extracts and Essential Oil(2015)
Combined qm/mm, biochemical, and structural studie, suggested target	Celastrol inhibits Plasmodium falciparum enoyl-acyl carrier protein reductase(2014)
Coumarin	Design, synthesis, and biological and crystallographic evaluation of novel inhibitors of Plasmodium falciparum enoyl-ACP-reductase (PfFabI)(2013)
Crystal structure of binding pockets, suggested target	New method for the assessment of all drug-like pockets across a structural genome(2008)
Diazaborine	Inhibitors of FabI, an enzyme drug target in the bacterial fatty acid biosynthesis pathway(2008)
Dihydroergotamine	Celastrol inhibits Plasmodium falciparum enoyl-acyl carrier protein reductase(2014)
ENA1096786	Identification of PfENR inhibitors: A hybrid structure-based approach in conjunction with molecular dynamics simulations(2018)
Epicatechin gallate	Inhibition of Plasmodium falciparum fatty acid biosynthesis: evaluation of FabG, FabZ, and FabI as drug targets for flavonoids(2006) Compound prioritization from inverse docking experiment using receptor-centric and ligand-centric methods: a case study on Plasmodium falciparum Fab enzymes(2014)
Epigallocatechin gallate	Inhibition of Plasmodium falciparum fatty acid biosynthesis: evaluation of FabG, FabZ, and FabI as drug targets for flavonoids(2006) Epigallocatechin gallate is a slow-tight binding inhibitor of enoyl-ACP reductase from Plasmodium falciparum(2008) Compound prioritization from inverse docking experiment using receptor-centric and ligand-centric methods: a case study on Plasmodium falciparum Fab enzymes(2014)
Ethionamide	A systematic in silico search for target similarity identifies several approved drugs with potential activity against the Plasmodium falciparum apicoplast(2013)
Eupatin	Antiprotozoal Effect of Artemisia indica Extracts and Essential Oil(2015)
Evernic acid	Potential of lichen secondary metabolites against Plasmodium liver stage parasites with FAS-II as the potential target(2013)
Fisetin	Compound prioritization from inverse docking experiment using receptor-centric and ligand-centric methods: a case study on Plasmodium falciparum Fab enzymes(2014)
Gallocatechin gallate	Inhibition of Plasmodium falciparum fatty acid biosynthesis: evaluation of FabG, FabZ, and FabI as drug targets for flavonoids(2006) Compound prioritization from inverse docking experiment using receptor-centric and ligand-centric methods: a case study on Plasmodium falciparum Fab enzymes(2014)
Gambogic acid	Celastrol inhibits Plasmodium falciparum enoyl-acyl carrier protein reductase(2014)
Glutaric anhydride	Design, synthesis, and application of novel triclosan prodrugs as potential antimalarial and antibacterial agents(2008)
GNF-Pf-2994	A Multilayer Network Approach for Guiding Drug Repositioning in Neglected Diseases(2016)
GNF-Pf-3214	A Multilayer Network Approach for Guiding Drug Repositioning in Neglected Diseases(2016)
GNF-Pf-3769	A Multilayer Network Approach for Guiding Drug Repositioning in Neglected Diseases(2016)
GNF-Pf-5368	A Multilayer Network Approach for Guiding Drug Repositioning in Neglected Diseases(2016)
Isatin	Integrated ligand and structure based studies of flavonoids as fatty acid biosynthesis inhibitors of Plasmodium falciparum(2010)
Isorhamnetin	Compound prioritization from inverse docking experiment using receptor-centric and ligand-centric methods: a case study on Plasmodium falciparum Fab enzymes(2014)
Kaempferol	Compound prioritization from inverse docking experiment using receptor-centric and ligand-centric methods: a case study on Plasmodium falciparum Fab enzymes(2014)
Ladanein	Integrated ligand and structure based studies of flavonoids as fatty acid biosynthesis inhibitors of Plasmodium falciparum(2010)
Levulinic acid	Design, synthesis, and application of novel triclosan prodrugs as potential antimalarial and antibacterial agents(2008)
Luteolin	Inhibition of Plasmodium falciparum fatty acid biosynthesis: evaluation of FabG, FabZ, and FabI as drug targets for flavonoids(2006) Integrated ligand and structure based studies of flavonoids as fatty acid biosynthesis inhibitors of Plasmodium falciparum(2010)
Mono-(dimethylaminoethyl) glutarate	Design, synthesis, and application of novel triclosan prodrugs as potential antimalarial and antibacterial agents(2008)
Morin	Compound prioritization from inverse docking experiment using receptor-centric and ligand-centric methods: a case study on Plasmodium falciparum Fab enzymes(2014)
Myricetin	Compound prioritization from inverse docking experiment using receptor-centric and ligand-centric methods: a case study on Plasmodium falciparum Fab enzymes(2014)
N,n-dimethyl aminopropylamine	Synthesis and bio-evaluation of alkylaminoaryl phenyl cyclopropyl methanones as antitubercular and antimalarial agents(2010)
N-[(Z)-(5-bromo-2-hydroxy-phenyl)methyleneamino]-4-(1-piperidylsulfonyl)benzamide	Discovery of novel inhibitors targeting enoyl-acyl carrier protein reductase in Plasmodium falciparum by structure-based virtual screening(2007)
N-[(Z)-(5-chloro-2-hydroxy-phenyl)methyleneamino]-4-(1-piperidylsulfonyl)benzamide	Discovery of novel inhibitors targeting enoyl-acyl carrier protein reductase in Plasmodium falciparum by structure-based virtual screening(2007)
N-acetyl-Leu-Leu-norLeu	Mass spectrometry-based systems approach for identification of inhibitors of Plasmodium falciparum fatty acid synthase(2007) Novel type II fatty acid biosynthesis (FAS II) inhibitors as multistage antimalarial agents(2013)
Nas-21/91	Mass spectrometry-based systems approach for identification of inhibitors of Plasmodium falciparum fatty acid synthase(2007)
N-benzylidene-4-phenyl-1,3-thiazol-2-amine	Molecular modeling studies, synthesis, and biological evaluation of Plasmodium falciparum enoyl-acyl carrier protein reductase (PfENR) inhibitors(2009)
Oroidin	Novel type II fatty acid biosynthesis (FAS II) inhibitors as multistage antimalarial agents(2013)
Pentacyano(isoniazid)ferrate	Enzyme Mechanism and Slow-Onset Inhibition of Plasmodium falciparum Enoyl-Acyl Carrier Protein Reductase by an Inorganic Complex(2011)
Phenylaminoacetic acid	Design, synthesis, structural characterization by IR, (1) H, (13) C, (15) N, 2D-NMR, X-ray diffraction and evaluation of a new class of phenylaminoacetic acid benzylidene hydrazines as pfENR inhibitors(2013)
Piplartine	In silico evaluation and in vitro growth inhibition of Plasmodium falciparum by natural amides and synthetic analogs(2020)
Psoromic acid	Potential of lichen secondary metabolites against Plasmodium liver stage parasites with FAS-II as the potential target(2013)
Quercetin	Integrated ligand and structure based studies of flavonoids as fatty acid biosynthesis inhibitors of Plasmodium falciparum(2010)
Quinine	Prioritization of active antimalarials using structural interaction profile of Plasmodium falciparum enoyl-acyl carrier protein reductase (PfENR)-triclosan derivatives(2015)
Rhodanine	Discovery of new potential hits of Plasmodium falciparum enoyl-ACP reductase through ligand- and structure-based drug design approaches(2013)
Rhodanine-furans	SAR and pharmacophore models for the rhodanine inhibitors of Plasmodium falciparum enoyl-acyl carrier protein reductase(2010)
Rhodanine-phenyls	SAR and pharmacophore models for the rhodanine inhibitors of Plasmodium falciparum enoyl-acyl carrier protein reductase(2010)
scrolepidoside	Anti-protozoal and plasmodial FabI enzyme inhibiting metabolites of Scrophularia lepidota roots(2005)
Succinamic acid	Design, synthesis, and application of novel triclosan prodrugs as potential antimalarial and antibacterial agents(2008)
Taurine	Marine natural products from the Turkish sponge Agelas oroides that inhibit the enoyl reductases from Plasmodium falciparum, Mycobacterium tuberculosis and Escherichia coli(2007)
TCMDC-125717	A Multilayer Network Approach for Guiding Drug Repositioning in Neglected Diseases(2016)
Thiodiazaborine	Inhibitors of FabI, an enzyme drug target in the bacterial fatty acid biosynthesis pathway(2008)
Triclosan	Triclosan offers protection against blood stages of malaria by inhibiting enoyl-ACP reductase of Plasmodium falciparum(2001) Kinetic determinants of the interaction of enoyl-ACP reductase from Plasmodium falciparum with its substrates and inhibitors(2001) Paradigm shifts in malaria parasite biochemistry and anti-malarial chemotherapy(2002) Targeting tuberculosis and malaria through inhibition of Enoyl reductase: compound activity and structural data(2003) Slow-tight-binding inhibition of enoyl-acyl carrier protein reductase from Plasmodium falciparum by triclosan(2004) Kinetic and structural analysis of the increased affinity of enoyl-ACP (acyl-carrier protein) reductase for triclosan in the presence of NAD+(2004) Mutational analysis of the triclosan-binding region of enoyl-ACP (acyl-carrier protein) reductase from Plasmodium falciparum(2004) Formulation and characterization of triclosan sub-micron emulsions and nanocapsules(2004) Synthesis and biological activity of diaryl ether inhibitors of malarial enoyl acyl carrier protein reductase. Part 2: 2'-substituted triclosan derivatives(2006) Inhibitors of nonhousekeeping functions of the apicoplast defy delayed death in Plasmodium falciparum(2007) Enoyl reductases as targets for the development of anti-tubercular and anti-malarial agents(2007) Mass spectrometry-based systems approach for identification of inhibitors of Plasmodium falciparum fatty acid synthase(2007) Epigallocatechin gallate is a slow-tight binding inhibitor of enoyl-ACP reductase from Plasmodium falciparum(2008) Malaria pulls a FASt one(2008) Design and in silico screening of combinatorial library of antimalarial analogs of triclosan inhibiting Plasmodium falciparum enoyl-acyl carrier protein reductase(2009) X-ray crystallographic analysis of the complexes of enoyl acyl carrier protein reductase of Plasmodium falciparum with triclosan variants to elucidate the importance of different functional groups in enzyme inhibition(2010) Antimalarial drug targets in Plasmodium falciparum predicted by stage-specific metabolic network analysis(2010) 3D-QSAR studies on triclosan derivatives as Plasmodium falciparum enoyl acyl carrier reductase inhibitors(2010) Effect of substrate binding loop mutations on the structure, kinetics, and inhibition of enoyl acyl carrier protein reductase from Plasmodium falciparum(2011) Novel type II fatty acid biosynthesis (FAS II) inhibitors as multistage antimalarial agents(2013) A systematic in silico search for target similarity identifies several approved drugs with potential activity against the Plasmodium falciparum apicoplast(2013) Modification of triclosan scaffold in search of improved inhibitors for enoyl-acyl carrier protein (ACP) reductase in Toxoplasma gondii(2013)
Triclosan	Structural elucidation of the specificity of the antibacterial agent triclosan for malarial enoyl acyl carrier protein reductase(2002) The fatty acid biosynthesis enzyme FabI plays a key role in the development of liver-stage malarial parasites(2008) Benzothiophene carboxamide derivatives as inhibitors of Plasmodium falciparum enoyl-ACP reductase(2011)
UKR1308259	Identification of PfENR inhibitors: A hybrid structure-based approach in conjunction with molecular dynamics simulations(2018)
Usnic acid	Potential of lichen secondary metabolites against Plasmodium liver stage parasites with FAS-II as the potential target(2013)
Virtual screening	Dynamics of Plasmodium falciparum enoyl-ACP reductase and implications on drug discovery(2012)
Vulpic acid	Potential of lichen secondary metabolites against Plasmodium liver stage parasites with FAS-II as the potential target(2013)