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Subcellular Localization

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Affecting Drugs
Drug Name	PubMed Articles (year of publication)
Biological characterization suggested target	Plasmodium falciparum MLH is schizont stage specific endonuclease(2012)
Daunorubicin	ATPase activity of Plasmodium falciparum MLH is inhibited by DNA-interacting ligands and dsRNAs of MLH along with UvrD curtail malaria parasite growth(2017)
Ethidium bromide	ATPase activity of Plasmodium falciparum MLH is inhibited by DNA-interacting ligands and dsRNAs of MLH along with UvrD curtail malaria parasite growth(2017)
etoposide	ATPase activity of Plasmodium falciparum MLH is inhibited by DNA-interacting ligands and dsRNAs of MLH along with UvrD curtail malaria parasite growth(2017)
Netropsin	ATPase activity of Plasmodium falciparum MLH is inhibited by DNA-interacting ligands and dsRNAs of MLH along with UvrD curtail malaria parasite growth(2017)
nogalamycin a	ATPase activity of Plasmodium falciparum MLH is inhibited by DNA-interacting ligands and dsRNAs of MLH along with UvrD curtail malaria parasite growth(2017)
Present in rapid production of drug resistance, suggested target	Malaria drug resistance is associated with defective DNA mismatch repair(2011)