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Subcellular Localization

• Picture 1

PDB protein strucure

• 4WI1
• 5IFU
• 4Q15
• 6T7K
• 4OLF
• 4YDQ

Affecting Drugs
Drug Name	PubMed Articles (year of publication)
3-(cyclohexanecarboxamido)-N-(2,3-dihydro-1H-inden-2-yl)pyrazine-2-carboxamide	Elucidating the path to Plasmodium prolyl-tRNA synthetase inhibitors that overcome halofuginone resistance(2022)
4-((1H-indol-3-yl)methyl)-1-butyl-1,2-dihydro-6H-pyrazino[2,1-b]quinazoline-3,6(4H)-dione	Indole-Containing Pyrazino[2,1- b]quinazoline-3,6-diones Active against Plasmodium and Trypanosomatids(2022)
epi-febrifuginol	Targeting Prolyl-tRNA Synthetase to Accelerate Drug Discovery against Malaria, Leishmaniasis, Toxoplasmosis, Cryptosporidiosis, and Coccidiosis(2017)
Febrifugine	Halofuginone and other febrifugine derivatives inhibit prolyl-tRNA synthetase(2012) Structural and functional analysis of the anti-malarial drug target prolyl-tRNA synthetase(2014) The cytoplasmic prolyl-tRNA synthetase of the malaria parasite is a dual-stage target of febrifugine and its analogs(2015) Using in Vitro Evolution and Whole Genome Analysis To Discover Next Generation Targets for Antimalarial Drug Discovery(2018)
febrifuginol	Targeting Prolyl-tRNA Synthetase to Accelerate Drug Discovery against Malaria, Leishmaniasis, Toxoplasmosis, Cryptosporidiosis, and Coccidiosis(2017)
Halofuginol	The cytoplasmic prolyl-tRNA synthetase of the malaria parasite is a dual-stage target of febrifugine and its analogs(2015)
Halofuginone	Structural and functional analysis of the anti-malarial drug target prolyl-tRNA synthetase(2014) The cytoplasmic prolyl-tRNA synthetase of the malaria parasite is a dual-stage target of febrifugine and its analogs(2015) Using in Vitro Evolution and Whole Genome Analysis To Discover Next Generation Targets for Antimalarial Drug Discovery(2018)
Ncgc00015280	Structure of Prolyl-tRNA Synthetase-Halofuginone Complex Provides Basis for Development of Drugs against Malaria and Toxoplasmosis(2015)
Protein biology suggested target	Structure of Prolyl-tRNA Synthetase-Halofuginone Complex Provides Basis for Development of Drugs against Malaria and Toxoplasmosis(2015)
Raltitrexed	In silico assessment of natural products and approved drugs as potential inhibitory scaffolds targeting aminoacyl-tRNA synthetases from Plasmodium(2020)