You can find more information about PF3D7_1408100-histo-aspartic protease using the following links:

PDB protein strucure

• 3FNS
• 3FNT
• 3FNU
• 3QVC
• 3QVI
• 6KUC
• 6KUB
• 6KUD

Affecting Drugs
Drug Name	PubMed Articles (year of publication)
(4R)-N-tert-Butyl-3-[(2S,3S)-2-hydroxy-3-({N-[(isoquinolin-5-yloxy)acetyl]-S-methyl-L-cysteinyl}amino)-4-phenylbutanoyl]-1,3-thiazolidine-4-carboxamide	High-affinity inhibition of a family of Plasmodium falciparum proteases by a designed adaptive inhibitor(2003)
4-(5-(4-methoxyphenyl)- 1’phenyl-3’-(p-tolyl)-3,4- 1’H,2H-[3,4’-bipyrazol]-2- yl)benezenesulfonamide	Molecular docking and dynamics studies on novel benzene sulfonamide substituted pyrazole-pyrazoline analogues as potent inhibitors of Plasmodium falciparum Histo aspartic protease(2020)
Alln	Role of Plasmodium falciparum digestive vacuole plasmepsins in the specificity and antimalarial mode of action of cysteine and aspartic protease inhibitors(2009)
Atazanavir	Critical roles for the digestive vacuole plasmepsins of Plasmodium falciparum in vacuolar function(2007)
Diphenylurea	Role of Plasmodium falciparum digestive vacuole plasmepsins in the specificity and antimalarial mode of action of cysteine and aspartic protease inhibitors(2009)
Doxorubicin	Discovery of plasmepsin inhibitors by fragment-based docking and consensus scoring(2009)
E-64	Critical roles for the digestive vacuole plasmepsins of Plasmodium falciparum in vacuolar function(2007) Role of Plasmodium falciparum digestive vacuole plasmepsins in the specificity and antimalarial mode of action of cysteine and aspartic protease inhibitors(2009)
Fragment-based docking and consensus scoring, halofantrine, doxorubicin, lumefantrine	Discovery of plasmepsin inhibitors by fragment-based docking and consensus scoring(2009)
G16	Functional profiling, identification, and inhibition of plasmepsins in intraerythrocytic malaria parasites(2009)
Halofantrine	Discovery of plasmepsin inhibitors by fragment-based docking and consensus scoring(2009)
Indinavir	Critical roles for the digestive vacuole plasmepsins of Plasmodium falciparum in vacuolar function(2007)
Kni-10006	Crystal structures of the histo-aspartic protease (HAP) from Plasmodium falciparum(2009)
Kni-10395	Structural insights into the activation and inhibition of histo-aspartic protease from Plasmodium falciparum(2011)
Leupeptin	Critical roles for the digestive vacuole plasmepsins of Plasmodium falciparum in vacuolar function(2007) Role of Plasmodium falciparum digestive vacuole plasmepsins in the specificity and antimalarial mode of action of cysteine and aspartic protease inhibitors(2009)
Lopinavir	Critical roles for the digestive vacuole plasmepsins of Plasmodium falciparum in vacuolar function(2007)
Lumefantrine	Discovery of plasmepsin inhibitors by fragment-based docking and consensus scoring(2009)
Nelfinavir	Critical roles for the digestive vacuole plasmepsins of Plasmodium falciparum in vacuolar function(2007)
Pepstatin a	Crystal structures of the histo-aspartic protease (HAP) from Plasmodium falciparum(2009) Antimalarial activity of thiosemicarbazones and purine derived nitriles(2009) Role of Plasmodium falciparum digestive vacuole plasmepsins in the specificity and antimalarial mode of action of cysteine and aspartic protease inhibitors(2009) Molecular modeling and prediction of binding mode and relative binding affinity of Art-Qui-OH with P. falciparum Histo-Aspartic Protease (HAP)(2012)
Purine	Antimalarial activity of thiosemicarbazones and purine derived nitriles(2009)
Ritonavir	Critical roles for the digestive vacuole plasmepsins of Plasmodium falciparum in vacuolar function(2007)
Ro 40-4388	Role of Plasmodium falciparum digestive vacuole plasmepsins in the specificity and antimalarial mode of action of cysteine and aspartic protease inhibitors(2009)
Saquinavir	Critical roles for the digestive vacuole plasmepsins of Plasmodium falciparum in vacuolar function(2007)
Sucralfate	A systematic in silico search for target similarity identifies several approved drugs with potential activity against the Plasmodium falciparum apicoplast(2013)
Suggested target	Genetic disruption of the Plasmodium falciparum digestive vacuole plasmepsins demonstrates their functional redundancy(2004)
X-ray structures and 3d models , suggested target	Predicting functional residues in Plasmodium falciparum plasmepsins by combining sequence and structural analysis with molecular dynamics simulations(2008)
ZINC02619047	Unveiling a New Era in Malaria Therapeutics: A Tailored Molecular Approach Towards the Design of Plasmepsin IX Inhibitors(2019)