You can find more information about PF3D7_1419300-glutathione S-transferase using the following links:

Subcellular Localization

• Picture 1

PDB protein strucure

• 1PA3
• 1Q4J
• 1OKT
• 2AAW
• 3FR3
• 3FR6
• 3FRC
• 3FR9
• 4ZXG

Affecting Drugs
Drug Name	PubMed Articles (year of publication)
2-(4-cholorophenyl)-N-(2,4,6-triisopropylphenylsulfonyloxy)acetimidamide	In Silico Exploration for New Antimalarials: Arylsulfonyloxy Acetimidamides as Prospective Agents(2015)
Bisindolylmaleimide ii	Identification of potential multitarget antimalarial drugs(2005)
Cdnb	Glutathione-S-transferases from chloroquine-resistant and -sensitive strains of Plasmodium falciparum: what are their differences?(2004)
Chloroquine	Potential role of Plasmodium falciparum exported protein 1 in the chloroquine mode of action(2018)
Cibacron blue	Glutathione S-transferase of the malarial parasite Plasmodium falciparum: characterization of a potential drug target(2002) Assembly of ligands interaction models for glutathione-S-transferases from Plasmodium falciparum, human and mouse using enzyme kinetics and molecular docking(2016)
Coruleoellagic acid	Compounds structurally related to ellagic acid show improved antiplasmodial activity(2009)
Crystal structure, suggested target	X-ray structure of glutathione S-transferase from the malarial parasite Plasmodium falciparum(2003)
Difference frin human enzyme, suggested target	Asn112 in Plasmodium falciparum glutathione S-transferase is essential for induced reversible tetramerization by phosphate or pyrophosphate(2014)
Diglycosylated diaminoalkanes	Synthesis and biological evaluation of potential modulators of malarial glutathione-S-transferase(s)(2007)
Ellagic acid	Compounds structurally related to ellagic acid show improved antiplasmodial activity(2009)
Ethacrynic acid	Glutathione-S-transferases from chloroquine-resistant and -sensitive strains of Plasmodium falciparum: what are their differences?(2004) Assembly of ligands interaction models for glutathione-S-transferases from Plasmodium falciparum, human and mouse using enzyme kinetics and molecular docking(2016)
Flavellagic acid	Compounds structurally related to ellagic acid show improved antiplasmodial activity(2009)
Glutathione	Glutathione mediated regulation of oligomeric structure and functional activity of Plasmodium falciparum glutathione S-transferase(2007)
Glycosyl amino acids	Synthesis and biological evaluation of potential modulators of malarial glutathione-S-transferase(s)(2007)
Glycosyl amino ester	Synthesis and biological evaluation of potential modulators of malarial glutathione-S-transferase(s)(2007)
Glycosyl hydroxamate	Synthesis and biological evaluation of potential modulators of malarial glutathione-S-transferase(s)(2007)
Glycosyl peptide	Synthesis and biological evaluation of potential modulators of malarial glutathione-S-transferase(s)(2007)
Gw844520	Identification of potential multitarget antimalarial drugs(2005)
Hemin	Tetramerization and cooperativity in Plasmodium falciparum glutathione S-transferase are mediated by atypic loop 113-119(2009) Assembly of ligands interaction models for glutathione-S-transferases from Plasmodium falciparum, human and mouse using enzyme kinetics and molecular docking(2016)
Knipholone	Multi-target molecular dynamic simulations reveal glutathione-S-transferase as the most favorable drug target of knipholone in Plasmodium falciparum(2023)
Metabolic network analysis, suggested target	Antimalarial drug targets in Plasmodium falciparum predicted by stage-specific metabolic network analysis(2010)
Protoporphyrin ix	Glutathione S-transferase of the malarial parasite Plasmodium falciparum: characterization of a potential drug target(2002) Assembly of ligands interaction models for glutathione-S-transferases from Plasmodium falciparum, human and mouse using enzyme kinetics and molecular docking(2016)
S-hexyl glutathione	Assembly of ligands interaction models for glutathione-S-transferases from Plasmodium falciparum, human and mouse using enzyme kinetics and molecular docking(2016)
S-hexylglutathione	Glutathione S-transferase of the malarial parasite Plasmodium falciparum: characterization of a potential drug target(2002)
Suggested target	Native and inhibited structure of a Mu class-related glutathione S-transferase from Plasmodium falciparum(2004) Plasmodium falciparum glutathione S-transferase--structural and mechanistic studies on ligand binding and enzyme inhibition(2006) Glutathione S-transferase from malarial parasites: structural and functional aspects(2005) The thiol-based redox networks of pathogens: unexploited targets in the search for new drugs(2006)
Thermodynamic characterization, suggested target	Calorimetric studies of ligands binding to glutathione S-transferase from the malarial parasite Plasmodium falciparum(2013)
Tmpyp4	Identification of potential multitarget antimalarial drugs(2005)
U-74389g	Identification of potential multitarget antimalarial drugs(2005)
ZINC00627448	In Silico Exploration for New Antimalarials: Arylsulfonyloxy Acetimidamides as Prospective Agents(2015)
ZINC49575668	In Silico Exploration for New Antimalarials: Arylsulfonyloxy Acetimidamides as Prospective Agents(2015)
ZINC79315625	In Silico Exploration for New Antimalarials: Arylsulfonyloxy Acetimidamides as Prospective Agents(2015)