You can find more information about PF3D7_1467300-1-deoxy-D-xylulose-5-phosphate reductoisomerase using the following links:

PlasmoDB - the Plasmodium genome resource
The TDR Targets Database

Subcellular Localization

PDB protein strucure

Affecting Drugs
Drug Name PubMed Articles (year of publication)
((2,4-difluorocyclohexyl)((2-(hydroxy(methyl)amino)-2-oxoethyl)sulfonyl)methyl)phosphonic acid
((2,4-difluorocyclohexyl)((2-(hydroxy(methyl)amino)-2-oxoethyl)thio)methyl)phosphonic acid
((3,4-dichlorophenyl)((2-(hydroxy(methyl)amino)-2-oxoethyl)thio)methyl)phosphonic acid
((3,4-dichlorophenyl)((2-(methyl(l1-oxidaneyl)amino)-2-oxoethyl)thio)methyl)phosphonic acid
(3-(N-([1,1'-biphenyl]-4-yloxy)acetamido)propyl)phosphonic acid
[({[(2,2-dimethylpropanoyl)oxy]methoxy}[(1E)-3-(N-hydroxyformamido)prop-1-en-1- yl]phosphoryl)oxy]methyl 2,2-dimethylpropanoate (
[(2,2-dimethyl-1-methylene-propoxy)methoxy-(1-hydroxy-2-oxo-4-piperidyl)phosphoryl]oxymethyl 2,2-dimethylpropanoate;oxido ammonium
[(3,4-difluorophenyl)-[2-[hydroxy(methyl)amino]-2-oxo-ethoxy]methyl]phosphonic acid
[1-(3,4-difluorophenyl)-4-(hydroxyamino)-4-oxo-butyl]phosphonic acid
[1-(3,4-difluorophenyl)-4-[hydroxy(methyl)amino]-4-oxo-butyl]phosphonic acid
[2-(cyclohexa-2,4-dien-1-ylmethyl)-4-[hydroxy(methyl)amino]-4-oxo-butyl]phosphonic acid
[2-cyclohexa-2,4-dien-1-yl-4-[hydroxy(methyl)amino]-4-oxo-butyl]phosphonic acid
[4-(hydroxyamino)-4-oxo-1-phenyl-butyl]phosphonic acid
[4-[hydroxy(methyl)amino]-4-oxo-1-phenyl-butyl]phosphonic acid
[5-cyclohexa-2,4-dien-1-yl-2-[2-[hydroxy(methyl)amino]-2-oxo-ethyl]pentyl]phosphonic acid
{3-[Acetyl(hydroxy)amino]propyl}phosphonic acid
1-(2-ethylsulfonylethyl)-2-methyl-5-nitro-imidazole (1EMI)
2,2-Dimethyl-propionic acid (2,2-dimethyl-propionyloxymethoxy)-[3-(formyl-hydroxy-amino)-1-methylpropyl]-phosphinoyloxymethyl ester
2,2-Dimethyl-propionic acid [3-(acetyl-hydroxyamino)-1-methyl-propyl]-(2,2-dimethyl-propionyloxymethoxy)-phosphinoyloxymethyl ester
2,4-bis(3-bromophenyl)-2-methyl-2,3-dihydro-1H-benzo[b][1,4] diazepine
2-[acetoxymethoxy-[(E)-3-[acetyl(hydroxy)amino]prop-1-enyl]phosphoryl]oxyethyl acetate
2-octadecynoic acid
3,3-dimethyl-11-phenyl2,3,4,5,10,11-hexahydro1Hdibenzo[b,e][1,4]diazepin1-one
3-[acetyl(hydroxy)amino]propylphosphonic acid
3-[formyl(hydroxy)amino]propylphosphonic acid
3'-amido-3'-deoxy-n(6)-(1-naphthylmethyl)adenosines
3-d model, suggested target
4-(hydroxyamino)-4-oxobutylphosphonic acid
4-[hydroxy(methyl)amino]-4-oxobutyl phosphonic acid
7- (4-chlorophenyl)-1-[3,4-dihydroxy-5-(hydroxymethyl) tetrahydro-2-furanyl]-2,4 (1H,3H)-pteridinedione
Amodiaquine
Aplysinone d
Araplysillin i
Araplysillin n20-formamide
Artesunate
Atovaquone
Benzimidazol-(2-yl)pentan-1-amine
Bis(pivaloyloxymethyl) ester
Cassiarin-D
Chembridge 19754435
Chembridge 54282478
Flavonoids
fosfoxacin
fosmidomycin
Fosmidomycin cyclopropyl analogues
Fr-33289
FR900098
Fr-900098
Furosemide
Galloyl triterpene
Heme
Hmbpp
Homoaerothionin,
Hydroxamic acid
hydroxy-[hydroxy-[2-[2-[hydroxy(methyl)amino]-2-oxo-ethyl]-5-(m-tolyl)pentyl]phosphoryl]sodium(1+)
Hydroxyfosmidomycin
Imidazolopiperazine
Immucillin
Ligand-binding sites suggested target
Mefloquine
methyl (1-(3,4-difluorocyclohexyl)-4-(hydroxyamino)-4-oxobutyl)phosphonate
Mmv008138
Morpholino oligomer
Mutations decrease pfdxr affinity, suggested target
Oleanolic acid 28-O-beta-D-glucopyranoside
PfDXR-PPMO
Sodium Hydrogen 2-((N-Hydroxy-N-methylcarbamoyl)methyl)-5-phenylpentylphosphonate
Sodium Hydrogen 2-((N-Hydroxy-N-methylcarbamoyl)methyl)-6-phenylhexylphosphonate
Suggested target
Thiosemicarbazone
Triclosan
X-ray crystal, suggested target