Conditional knockdown of PfPMRT1 has no effect during gametocyte development. Live cell microscopy of 3D7-iGP-PfPMRT1-GFP stage I – V

gametocytes. Scale bar, 2 μm. Conditional knockdown of PfPMRT1 via the glmS ribozyme system resulted in a reduction in PfPMRT1-GFP fluorescence intensity of 79.4% (+/- SD 9.2%) at 7 days post induction (dpi) or 75.5% (+/- SD 23.2%) at 10 dpi, without an effect on gametocyte development

Wichers JS, Mesén-Ramírez P, Fuchs G, Yu-Strzelczyk J, Stäcker J, von Thien H, Alder A, Henshall I, Liffner B, Nagel G, Löw C, Wilson D, Spielmann T, Gao S, Gilberger TW, Bachmann A, Strauss J. PMRT1, a Plasmodium-Specific Parasite Plasma Membrane Transporter, Is Essential for Asexual and Sexual Blood Stage Development. mBio. 2022 13(2):e0062322. PMID: 35404116;