Complex formation and subcellular localization of the LCCL-domain protein complexes. PfCCp-based complexes in the gametocytes and macrogametes of P. falciparum. The proposed protein networks are shown, and their rearrangements during the sexual phases of the parasites are indicated. Cr, Crystalloid; GaPM, gamete plasma membrane; GPM, gametocyte plasma membrane; N, nucleus; PV, parasitophorous vacuole; PVM, PV membrane; RBC, red blood cell; RBCM, RBC membrane. Predicted interactions are proposed based on co-immunoprecipitations followed by Western blot analysis or mass spectrometry. P. falciparum: Dashed lines indicate further interactions strengthening the complex after gametogenesis. Bennink S, Pradel G. The Multiple Roles of LCCL Domain-Containing Proteins for Malaria Parasite Transmission. Microorganisms. 2024 12(2):279. PMID: 38399683;