Model of chromatin remodeling throughout P. falciparum’s erythrocytic cycle. Genome-wide variations of densities of coverage for MAINE-seq (red) and FAIRE-seq (black). After the invasion of a red blood cell by a parasite at its merozoite morphological stage, histones are depleted and chromatin loosens. During the ring stage, transcription occurs locally in a regulated manner. At the early trophozoite stage, histones are massively depleted. Replication and transcription factors can freely bind. DNA-related metabolic processes are permitted. After replication, DNA re-packs at the schizont stage and the parasites divide and escape the host as differentiated merozoites that are ready for a new cycle of infection. Ponts N, Harris EY, Prudhomme J, Wick I, Eckhardt-Ludka C, Hicks GR, Hardiman G, Lonardi S, Le Roch KG. Nucleosome landscape and control of transcription in the human malaria parasite. Genome Res. 2010 20(2):228-38. PMID: 20054063