Possible mechanism used by DPAP3 and PfSUB1 to regulate host cell rupture. Step 1: maturation of PfSUB1, which can be blocked by the DPAP3-selective inhibitor SAK1. Step 2: release of PfSUB1 into the parasitophorous vacuole (PV) and subsequent proteolysis of SERA5, which can be directly blocked by the inhibitor JCP104. Arastu-Kapur S, Ponder EL, Fonović UP, Yeoh S, Yuan F, Fonović M, Grainger M, Phillips CI, Powers JC, Bogyo M. Identification of proteases that regulate erythrocyte rupture by the malaria parasite Plasmodium falciparum. Nat Chem Biol. 2008 PMID: 18246061

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