Model of CLAG3.1 putative transmembrane domain and HVR insertion into the erythrocyte membrane. (A–C) Schematic illustrating a model for how a conformational change in the RhopH complex may drive insertion of the extracellular and putative transmembrane elements into the red blood cell plasma membrane. Ho CM, Jih J, Lai M, Li X, Goldberg DE, Beck JR, Zhou ZH. Native structure of the RhopH complex, a key determinant of malaria parasite nutrient acquisition. Proc Natl Acad Sci U S A. 2021 118(35):e2100514118.