Model for PfPLP1-mediated egress. An increase in intracellular Ca2+ triggers discharge of PfPLP1 from micronemes of merozoites leading to its localization on the host cell membrane. Localization of PfPLP1 on the membrane mediates its permeabilization and rupture facilitating egress of P. falciparum merozoites. Garg S, Agarwal S, Kumar S, Shams Yazdani S, Chitnis CE, Singh S. Calcium-dependent permeabilization of erythrocytes by a perforin-like protein during egress of malaria parasites. Nat Commun. 2013 4:1736. PMID: 23591903