PfPI4KIIIB inhibitors reduce protein secretion and export in P. falciparum. Fluorescence microscopy images of parasite infected RBCs treated with the brefeldin A (5μg/mL), torin 2 (10 nM), M-797(4.8μM), OGHL250 (3.1μM), WEHI-518 (200 nM), C3 (1.2 μM), and KDU731 (300 nM) (B). The cells were probed with rabbit anti-Nluc and an EXP2 mouse monoclonal to locate the Hyp1-Nluc reporter protein and the PVM, respectively. Nuclei were stained with DAPI, and the space bar indicates 4μm.

Ling DB, Nguyen W, Looker O, Razook Z, McCann K, Barry AE, Scheurer C, Wittlin S, Famodimu MT, Delves MJ, Bullen HE, Crabb BS, Sleebs BE, Gilson PR. A Pyridyl-Furan Series Developed from the Open Global Health Library Block Red Blood Cell Invasion and Protein Trafficking in Plasmodium falciparum through Potential Inhibition of the Parasite's PI4KIIIB Enzyme. ACS Infect Dis. 2023