The RS domain localizes PfSR1 to the nucleus. IFAs showing the localization of PfSR1 wasectopically express fused to a myc epitope tag and detected using anti-myc antibodies. PfSR1 (green); DAPI staining (blue); developmental stages are indicated on the left. (A) Cellular localization of PfSR1-myc. PfSR1 shuttles between the nucleus and cytoplasm. The cytoplasmic location is restricted to regions that are outside the parasite’s food vacuole. the nuclear location of PfSR1 at early ring stages is in a distinct punctuated pattern mainly at the nuclear periphery and is not equally spread all over the nucleus.

Eshar S, Allemand E, Sebag A, Glaser F, Muchardt C, Mandel-Gutfreund Y, Karni R, Dzikowski R. A novel Plasmodium falciparum SR protein is an alternative splicing factor required for the parasites' proliferation in human erythrocytes. Nucleic Acids Res. 2012 40(19):9903-16