Host S1P regulates PfHDAC-1-mediated deacetylation of histone. (B, panel I) Immunofluorescence micrographs of erythrocytes parasitized with Pf3D7 schizonts showing reduced histone acetylation upon treatment with PF-543 (2 μM) and SAHA (5 μM). The parasite nuclei are stained with Hoechst (blue). Scale bar: 5 μm. HDAC-1 could not be detected in the erythrocyte lysate. Sah RK, Anand S, Dar W, Jain R, Kumari G, Madan E, Saini M, Gupta A, Joshi N, Hada RS, Gupta N, Pati S, Singh S. Host-Erythrocytic Sphingosine-1-Phosphate Regulates Plasmodium Histone Deacetylase Activity and Exhibits Epigenetic Control over Cell Death and Differentiation. Microbiol Spectr. 2023 11(2):e0276622