A new model of PTEX interaction. Top panel, shown is an expanded view of PTEX interaction at the PVM. EXP2 has demonstrated the strongest membrane association of the three major PTEX components (EXP2, HSP101, and PTEX150) and is believed to interact most strongly with PTEX150, which in turn binds HSP101. Data generated here indicate that the PTEX components PTEX150 and HSP101 are made predominantly in schizogony and are stored with EXP2 within the dense granules (DG) before their release into the newly forming PVM during invasion. EXP2 is synthesized predominantly in the ring/trophozoite stage, and some synthesis of PTEX150 and HSP101 is also likely to occur during this stage. Baum J, Ralph SA, Cowman AF, de Koning-Ward TF, Crabb BS, Gilson PR. Biosynthesis, localization, and macromolecular arrangement of the Plasmodium falciparum translocon of exported proteins (PTEX). J Biol Chem. PMID: 22253438