Effect of Torin2 treatment on the PVM and UIS4 localization in young liver stage trophozoites. (C) Effect of Torin2 treatment on UIS4 and EXP1 during early liver stage schizogony. UIS4 and EXP1 were localized almost completely outside of the parasite soma in control. Torin2 treatment led to a dramatic mislocalization of UIS4 and EXP1, with signal largely found in the parasite soma.

Hanson KK, Ressurreição AS, Buchholz K, Prudêncio M, Herman-Ornelas JD, Rebelo M, Beatty WL, Wirth DF, Hänscheid T, Moreira R, Marti M, Mota MM. Torins are potent antimalarials that block replenishment of Plasmodium liver stage parasitophorous vacuole membrane proteins. Proc Natl Acad Sci U S A. 2013 110(30):E2838-47.