PF3D7_1305200 AP2 domain transcription factor, putative

. Structures and Proteins in Host Cell Cytosol Uptake (HCCU). (A) A red blood cell (RBC) infected with a Plasmodium falciparum parasite showing different

possible routes of HCCU. Routes I and II involve the cytostome (C), either as a de novo-formed structure, and pinching off of the entire cytostome (I, a–e), or as permanent structure (II, a,b). These possibilities are not mutually exclusive. III shows a phagotroph which could be a surface enlargement of the parasite without a function in endocytosis, an autonomous HCCU structure with similar options for delivery of HCC to the digestive vacuole (DV) as the cytostome, or a particular state of the cytostomal cycle (double-headed arrow with question mark). E, endosomal compartment; preDV, HCC-filled structure observed near the DV that might correspond to a compartment upstream of the DV. Arrows indicate possible transport routes that all are hypothetical. (B) Proteins known or suspected (indicated by question marks) to be involved in HCCU. Note that KIC1–9 signify proteins colocalizing with Kelch13, but only KIC7 has been experimentally shown to be involved in HCCU. Rab5x stands for Rab5b or Rab5c. Abbreviations: PPM, parasite plasma membrane; PVM, parasitophorous vacuolar membrane; V, HCC-containing vesicle. Spielmann T, Gras S, Sabitzki R, Meissner M. Endocytosis in Plasmodium and Toxoplasma Parasites. Trends Parasitol. 2020 36(6):520-532.

Other associated proteins

PFID Formal Annotation
PF3D7_0104300 ubiquitin carboxyl-terminal hydrolase 1, putative
PF3D7_0211200 ras-related protein Rab-5A
PF3D7_0216400 vacuolar protein sorting-associated protein 45, putative
PF3D7_0420300 AP2 domain transcription factor
PF3D7_0606000 kelch13 interaction candidate kic1
PF3D7_0613800 AP2 domain transcription factor, putative
PF3D7_0903200 ras-related protein RAB7
PF3D7_0934400 AP2 domain transcription factor, putative
PF3D7_1025000 eps15-like protein
PF3D7_1107800 AP2 domain transcription factor, putative
PF3D7_1115500 AP2 domain transcription factor, putative
PF3D7_1239200 transcription factor with AP2 domain(s)
PF3D7_1310600 ras-related protein Rab-5B secretory complex protein 61 alpha
PF3D7_1343700 kelch protein K13
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