Expression of MAHRP11-249-GFP at different stages of the intraerythrocytic cycle of P. falciparum. The images represent a DIC image, the GFP fluorescence signal, and an overlay of these images. Ring and trophozoite stage parasites (a to d) show puncta of fluorescence in the RBC cytoplasm which appear to represent peripheral Maurer’s clefts (white arrows). Some cells (see, e.g., panel c) show a ring of “beads” of fluorescence around the PV. These foci may represent nascent Maurer’s clefts (yellow arrows). Mature schizont-stage parasites (e) show flattening of the peripheral Maurer’s clefts against the RBC membrane. In a burst schizont (f), the remnant Maurer’s clefts remain associated with the lysed host cell membrane. Bar, 5mm.The intensities of the images were adjusted to optimize the fluorescence signal at each parasite stage. Spycher C, Rug M, Klonis N, Ferguson DJ, Cowman AF, Beck HP, Tilley L. Genesis of and trafficking to the Maurer's clefts of Plasmodium falciparum-infected erythrocytes. Mol Cell Biol. 2006 26(11):4074-85. PMID: 16705161