Orientation of DMT1 homologs in the FV membrane. Live-parasite fluorescence microscopy and proposed membrane topology of PfDMT1 (A) and yeast Smf3 (B). The intensity plots depict the normalized GFP fluorescence as a function of distance along the white line. The scissors in panel B represent FV proteases expected to cleave off a C-terminal GFP tag. Loveridge KM, Sigala PA. Identification of a divalent metal transporter required for cellular iron metabolism in malaria parasites. bioRxiv [Preprint]. 2024 PMID: 38798484