Summary of “Apicomplexan-specific” characteristics in their free-living relatives. (A) Classification of four groups of apicomplexan proteins based on distribution: horizontal gene transfers (HGTs), unique protein clusters [OrthoMCL and Wasmuth et al. (14)], and proteins associated with infection (Apiloc). Categories a – e correspond to the phylogenetic distribution of these proteins when free-living relatives are considered, which is broken down by specific processes and proteins in B . Note that putative GAP45 in Cryptosporidium is highly divergent (indicated by “?” in category d). Janouškovec J, Tikhonenkov DV, Burki F, Howe AT, Kolísko M, Mylnikov AP, Keeling PJ. Factors mediating plastid dependency and the origins of parasitism in apicomplexans and their close relatives. Proc Natl Acad Sci U S A. 2015 112(33):10200-7. PMID: 25717057