Model for regulation of PA homeostasis by PfPAP2 in malaria parasite. PA homeostasis maintained by PfPAP2 is essential for parasite growth. Blocking the PAP activity of PfPAP2 creates PA imbalance in P. falciparum. This breakdown in PA homeostasis promotes preterm egress of merozoites, which then fail to survive in the host environment leading to limited growth of parasite. PfPAP2 clearly stands out as an important regulator, maintaining the PA homeostasis that is crucial for parasite to flourish. Kumar Sah R, Garg S, Dangi P, Ponnusamy K, Singh S. Phosphatidic acid homeostasis regulated by a type-2 phosphatidic acid phosphatase represents a novel druggable target in malaria intervention. Cell Death Discov. 2019 5:107. PMID: 31263575;