PF3D7_1022700 phospholipid scramblase, plscr

Plasma membrane association is lost in parasites expressing the truncated PfPLSCR-GFP fusion protein, which distributes throughout the parasite cytosol. Schematic of the CRISPR-Cas9 mediated KO strategy. Expression of sfGFP is driven under a constitutive BiP promoter. Live-cell image of PfPLSCR KO parasites expressing sfGFP throughout asexual parasite development. Parasite nuclei are stained with DAPI (blue).

Haase S, Condron M, Miller D, Cherkaoui D, Jordan S, Gulbis JM, Baum J. Identification and characterisation of a phospholipid scramblase in the malaria parasite Plasmodium falciparum. Mol Biochem Parasitol. 2021 8:111374.

Other associated proteins

PFID Formal Annotation
PF3D7_0930300 merozoite surface protein 1