PF3D7_1456000 AP2 domain transcription factorAP2-HC

Upper panel: PfAP2-HC associates with PfHP1 throughout the genome. Representative IFA images of GFP-PfAP2-HC and PfHP1 localization in 3D7/GFP-PfAP2-HC parasites, 36–44 hpi. Nuclei were stained with DAPI. DIC, differential interference contrast. Scale bar, 5 mm. GFP-PfAP2-HCmatches that of PfHP1 in immunofluorescence assays (IFAs), where the two proteins appear to overlap Lower panel: PfAP2-HC depletion does not affect PfHP1 genome-wide coverage. Representative live cell fluorescence images of 3D7/DDGFP-PfAP2-HC schizonts (36–44 hpi) grown in the presence (+) or absence (-) of Shield-1. Nuclei were stained with Hoechst. DIC, differential interference contrast. Scale bar, 5 mm.

Carrington E, Cooijmans RHM, Keller D, Toenhake CG, Bártfai R, Voss TS. The ApiAP2 factor PfAP2-HC is an integral component of heterochromatin in the malaria parasite Plasmodium falciparum. iScience. 2021 24(5):102444.

Other associated proteins

PFID Formal Annotation
PF3D7_1220900 heterochromatin protein 1