PF3D7_0208500 acyl carrier protein

Apicoplast biogenesis requires linear polyprenyl isoprenoid synthesis. (A) 5 μM farnesol (FOH), geranylgeraniol (GGOH), or decaprenol (C50-OH), but not b-carotene rescues apicoplast biogenesis from inhibition by 10 μM FOS in PfMev parasites. Synchronized ring-stage parasites were incubated with the indicated treatments for 36 hours and imaged by brightfield (BF) or fluorescence microscopy, with visualization of parasite nuclei by Hoechst staining and the apicoplast by ACPL-GFP signal

Okada M, Rajaram K, Swift RP, Mixon A, Maschek JA, Prigge ST, Sigala PA. Critical role for isoprenoids in apicoplast biogenesis by malaria parasites. Elife. 2022 11:e73208.

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