PF3D7_0202000 knob-associated histidine-rich protein

Disruption of the PTP7 locus affects knob and cleft morphology. Indirect immunofluorescence microscopy of acetone/methanol fixed cells. Bright field (BF) and DAPI stained DNA (blue) images are merged. Scale bar, 2 μm Immunofluorescence microscopy of ΔPTP7 trophozoite-infected RBCs revealed no obvious change in the profiles of the Maurer’s cleft markers REX1 and MAHRP1; the EDV marker PTP2

Carmo OMS, Shami GJ, Cox D, Liu B, Blanch AJ, Tiash S, Tilley L, Dixon MWA. Deletion of the Plasmodium falciparum exported protein PTP7 leads to Maurer's clefts vesiculation, host cell remodeling defects, and loss of surface presentation of EMP1. PLoS Pathog. 2022 Aug 5;18(8):e1009882. doi: 10.1371/journal.ppat.1009882. Epub ahead of print.

Other associated proteins

PFID Formal Annotation
PF3D7_0731100 gametocyte exported protein 11 EMP1-trafficking protein
PF3D7_0935900 ring-exported protein 1
PF3D7_1370300 membrane associated histidine-rich protein