Disruption of the PTP7 locus affects knob and cleft morphology. Indirect immunofluorescence microscopy of acetone/methanol fixed cells. Bright field (BF) and DAPI stained DNA (blue) images are merged. Scale bar, 2 μm Immunofluorescence microscopy of ΔPTP7 trophozoite-infected RBCs revealed no obvious change in the profiles of the Maurer’s cleft markers REX1 and MAHRP1; the EDV marker PTP2
Carmo OMS, Shami GJ, Cox D, Liu B, Blanch AJ, Tiash S, Tilley L, Dixon MWA. Deletion of the Plasmodium falciparum exported protein PTP7 leads to Maurer's clefts vesiculation, host cell remodeling defects, and loss of surface presentation of EMP1. PLoS Pathog. 2022 Aug 5;18(8):e1009882. doi: 10.1371/journal.ppat.1009882. Epub ahead of print.
Other associated proteins
|PF3D7_0202000||knob-associated histidine-rich protein|
|PF3D7_0935900||ring-exported protein 1|
|PF3D7_1370300||membrane associated histidine-rich protein|