fC2DMA is expressed during asexual blood stages of P. falciparum. C. Localization of PfC2DMA within mature schizont and free merozoite; green represents PfC2DMA, red represents MSP-1. TD represents transmitted light channel. Parasite nuclei were stained with DAPI. D. The spatial organization of C2dom of PfC2DMA on parasite plasma membrane was also analyzed in merozoites under unpermeablized conditions. PfC2DMA was found to localize to the merozoite surface in punctated schizonts and individual merozoites (C). It colocalized with the GPI-anchored membrane protein marker, Merozoite Surface Protein-1 (MSP-1), suggesting that it localizes to parasite plasma membrane.
Munjal A, Kannan D, Singh S. A C2 domain containing plasma membrane protein of Plasmodium falciparum merozoites mediates calcium-dependent binding and invasion to host erythrocytes. J Microbiol Immunol Infect. 2022 6:S1684-1182(22)00105-0.
Other associated proteins
|PF3D7_1110100||conserved Plasmodium protein, unknown function|