PF3D7_0903700 alpha tubulin 1

Asexual blood-stage and sexual-stage phenotypes of Pfsrpk1- parasites. IFAs were performed on mature schizont stages for WT PfNF54 and Pfsrpk1- using thin culture smears with anti-PfMSP1 antisera, which labels the merozoite surface (red) in combination with anti-tubulin X antibodies, which would mark the subpellicular microtubules (green). Representative images are shown. The parasite DNA was visualized with DAPI (blue). Scale bar, 5 mm. Merge I, merged image for red and green panels; merge II, merged image for red, green, and DAPI (blue) channel. DIC, differential interference contrast; DAPI, 49,6-diamidino-2-phenylindole. IFAs were performed on WT PfNF54 and Pfsrpk12 mature stage V gametocytes culture thin smears using anti-PfP230p antisera, which labels the stage V male gametocytes (green) in combination with anti-Pfg377 antisera, which labels female gametocytes (red). Representative images are shown. The parasite DNA was visualized with DAPI (blue). Scale bar, 5 mm. Merge I, merged image for red and green panels; merge II, merged image for red, green, and DAPI (blue) channel. Symbols for male and female gametocytes are shown on the left sides of the image panels. PfSRPK1 Is Critical for Erythrocytic Stages

Dixit A, Singh PK, Sharma GP, Malhotra P, Sharma P. PfSRPK1, a novel splicing-related kinase from Plasmodium falciparum. J Biol Chem. 2010 3;285(49):38315-23.

Other associated proteins

PFID Formal Annotation
PF3D7_0208900 6-cysteine protein
PF3D7_0302100 serine/threonine protein kinase
PF3D7_1250100 osmiophilic body protein g377
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