Effect of downregulation of PfUSP on development of parasite endoplasmic
reticulum. Fluorescent microscope images of PfUSP transgenic parasites immuno-stained with anti-HA and anti-BiP antibody at different time points (30-42 h) in control and iKD sets. Parasites in PfUSP-iKD set showed disrupted development of ER having punctuated/fragmented morphology as compared to control set which showed continuous peri-nuclear ER. The parasite nuclei were stained with DAPI (blue) and parasites were visualized by confocal laser scanning microscope.
Caradec T, Trivelli X, Desmecht E, Peucelle V, Khalife J, Hartkoorn RC. Dactylosporolides: Glycosylated Macrolides from Dactylosporangium fulvum. J Nat Prod. 2022 PMID: 36512509.
Other associated proteins
|PF3D7_0403500||ubiquitin specific protease, putative|