PF3D7_0202000 knob-associated histidine-rich protein

PfHsp70-x partially associates with Maurer’s clefts but not with knobs: (A–B) Panel I: the signal for PfHsp70-x (green) was obtained in the parasite compartment along with few punctate spots in the erythrocyte compartment. Panel II: MAHRP1 (red) stained discrete foci representative of Maurer’s clefts in the erythrocyte periphery. Panel III: the DIC image of the infected erythrocyte. Panel IV: merged image overlaid with DIC image reveals that MAHRP1 and PfHsp70-x partially co-localize in the erythrocyte compartment, suggesting that PfHsp70-x possibly associates with Maurer’s clefts. (C-D) Panel I: the signal for PfHsp70-x (green) was obtained in the parasite compartment along with few punctate spots in the erythrocyte compartment. Panel II: KAHRP (red), being a constituent of knobs, stained the entire erythrocyte membrane. Panel III shows the DIC image of the infected erythrocyte. Panel IV: no co-localization is observed between KAHRP and PfHsp70-x, suggesting that PfHsp70-x does not associate with knobs on the infected erythrocyte membrane.

Grover M, Chaubey S, Ranade S, Tatu U. Identification of an exported heat shock protein 70 in Plasmodium falciparum. Parasite. 2013;20:2.

Other associated proteins

PFID Formal Annotation
PF3D7_0831700 PfHsp70-x
PF3D7_1370300 membrane associated histidine-rich protein
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