PF3D7_1222700 glideosome-associated protein 45

1. Co-localization of the TMD protein MAL13P1.130 and the glideosome associated protein GAP45. GAP45 was episomally expressed as mCherry fusion protein and localized in different schizont stages (left). Double transgenic cell line expressing MAL13P1.130-GFP and GAP45-mCherry reveals identical spatial distribution (right).

2. Coexpression of the centrosome marker PfCentrin3-GFP and PF14_0578-mCherry shows a very close association between the forming IMC and the centrosome, as PfCentrin3 marks the centre of the developing IMC cramp-structure. Nuclei stained with DAPI. Scale bars, 2 μm.

Kono M, Herrmann S, Loughran NB, Cabrera A, Engelberg K, Lehmann C, Sinha D, Prinz B, Ruch U, Heussler V, Spielman T, Parkinson J, Gilberger TW. Evolution and Architecture of the Inner Membrane Complex in Asexual and Sexual Stages of the Malaria Parasite. Mol Biol Evol. 2012 29(9):2113-32

Other associated proteins

PFID Formal Annotation
PF3D7_1027700 centrin-3
PF3D7_1323700 glideosome associated protein with multiple membrane spans 1
PF3D7_1460600 inner membrane complex sub-compartment protein 3
img