Live cell imaging of GFP tagged GAPMs (Glideosome Associated Protein with Multiple membrane spans) in Plasmodium falciparum indicate that they localize to the inner membrane complex. Developmental series of fluorescent images of live P. falciparum schizonts expressing PfGAPM1-GFP (A) or PfGAPM2-GFP (B) fusion proteins showing typical inner membrane complex morphology. During early schizogony, PfGAPM proteins are apparent as one or two small discs associated with each nucleus (i). Each disc is perforated by one or two small holes that may correspond to the future apical tip of the merozoite (ii). As the parasites mature the discs grow, ultimately encapsulating the mature merozoite except at the apical tip (red arrowhead) (iii,iv).

Bullen HE, Tonkin CJ, O'Donnell RA, Tham WH, Papenfuss AT, Gould S, Cowman AF, Crabb BS, Gilson PR. A novel family of apicomplexan glideosome associated proteins with an inner-membrane anchoring role. J Biol Chem. 2009 284(37):25353-63.