Mitotic microtubular structures of cultured parasites viewed by immunofluorescence using antibodies to P. falciparum b-tubulin (visualised with FITC, left) and DAPI nuclear stain (right). (a) Untreated: note microtubule-organising centres (small arrow) and hemispindles (large arrow); (b) treated with 20mM trifluralin: note dots of tubulin fluorescence (arrowheads) and loss of normal structures; (c) treated with 20mM oryzalin; (d) treated with 20mM APM. In all cases, exposure to inhibitor was for 6 h. Scale bars are 4 mm.

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