PF3D7_1011400 proteasome subunit beta type-5

Immunoelectron microscopy using anti-β-SU type 5 antisera in combination with gold (12 nm)-coupled secondary antibody indicated the ultrastructural localization of the protein in trophozoites and schizonts. Arrowheads indicate gold particles. Bar, 1 μm. β-SU type 5 is abundantly present in the nuclei of trophozoites and schizonts, but not in the nucleolus. The protein is additionally present in the cytoplasm of blood stage parasites. No gold labelling was detected in the erythrocyte, the parasite rhoptries or the food vacuole.

Aminake MN, Schoof S, Sologub L, Leubner M, Kirschner M, Arndt HD, Pradel G. Thiostrepton derivatives exhibit antimalarial and gametocytocidal activity by dually targeting parasite proteasome and apicoplast. Antimicrob Agents Chemother. 2011 55:1338-48.

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