Identification of a conserved motif of 11 amino acids in VTSs of parasite proteins exported to the erythrocyte. (A) VTS of proteins PfGBP 130 and PfEMP2 target GFP to the erythrocyte. Projections (0-) of live cells expressing GFP chimeras of a SS alone (a), SSVTSGBP130 (b), and SSVTSEMP2 (c). (B) Alignment of MEME motifs in VTSs of indicated five exported soluble proteins. Red bar underlines 5–amino acid MEME motif 1. Blue bar underlines 11–amino acid MEME motif 2. (C) Projections (0-) of live cells expressing GFP chimeras of full-length STEVOR (a) and SSVTSSTEVOR (b).
Hiller NL, Bhattacharjee S, van Ooij C, Liolios K, Harrison T, Lopez-Estraño C, Haldar K. A host-targeting signal in virulence proteins reveals a secretome in malarial infection. Science. 2004 306(5703):1934-7.
Other associated proteins
|PF3D7_0500800||erythrocyte membrane protein 2 mature parasite-infected erythrocyte surface antigen|