Trafficking of falcipain 2-GFP fusion proteins. Confocal microscope images showing expression and trafficking of Fal2-GFP fusion proteins at trophozoite stage of Fal2-S1. The chimeric GFP is visible in parasitophorous vacuole (arrow heads), and in the extension or evaginations of the parasitophorous vacuole (pointed arrows). Falcipain-2 is trafficked through a classical vesicle mediated secretory pathway involving endoplasmic reticulum and Golgi-like apparatus
Dasaradhi PV, Korde R, Thompson JK, Tanwar C, Nag TC, Chauhan VS, Cowman AF, Mohmmed A, Malhotra P. Food vacuole targeting and trafficking of falcipain-2, an important cysteine protease of human malaria parasite Plasmodium falciparum. Mol Biochem Parasitol. 2007 156:12-23. Copyright Elsevier 2009.