PF3D7_1116000 rhoptry neck protein 4

PfRON4 localizes to the rhoptry necks. Immuno-electron microscopy with MAb 24C6 and protein A-gold shows specific labeling in the rhoptry necks of P. falciparum schizonts. Infected human erythrocytes were embedded in LRWhite and stained with MAb 24C6. The enlarged area shows a longitudinally sectioned rhoptry with PfRON4 labeling restricted to the narrow apical end of the rhoptries in a maturing merozoite (arrows).

Alexander DL, Arastu-Kapur S, Dubremetz JF, Boothroyd JC. Plasmodium falciparum AMA1 binds a rhoptry neck protein homologous to TgRON4, a component of the moving junction in Toxoplasma gondii. Eukaryot Cell. 2006 5:1169-73.

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