Detection of S-antigen by immunogold labeling with anti-S-antigen antibodies on ultra-thin sections of wild-type P. falciparum parasites. A, in untreated early schizonts, S-antigen localizes to the parasitophorous vacuole. B, in untreated late schizonts, S-antigen localizes throughout the erythrocyte cytosol. C, in leupeptin- and chymostatin-treated early schizonts, S-antigen localizes to the parasitophorous vacuole. D, in leupeptin- and chymostatin-treated late schizonts, S-antigen localizes throughout the erythrocyte cytosol. Scale bar 1.0 mm.

Wickham ME, Culvenor JG, Cowman AF. Selective inhibition of a two-step egress of malaria parasites from the host erythrocyte. J Biol Chem. 2003 278:37658-63