EXP1 localizes to PVM domains with PTEX. Parasites were fixed at <15 min, 60–90 min and 20–21 h after invasion and labelled by IFA for EXP1 (red), EXP2 (green) and the nucleus (40,6–diamidino-2-phenylindole (DAPI), blue). (a) Imaging of all samples by widefield deconvolution microscopy (scale bar, 1 mm). when EXP2 localization was compared with that of a DRM-enriched protein, the exported protein 1 (EXP1), clear co-incidence of fluorescence was seen using widefield deconvolution microscopy of parasites fixed <15 min, 60–90 min and 20-21 h post invasion, although EXP1 appeared to become more widely distributed around the PVM in the latter sample.
Riglar DT, Rogers KL, Hanssen E, Turnbull L, Bullen HE, Charnaud SC, Przyborski J, Gilson PR, Whitchurch CB, Crabb BS, Baum J, Cowman AF. Spatial association with PTEX complexes defines regions for effector export into Plasmodium falciparum-infected erythrocytes. Nat Commun. 2013 Jan 29;4:1415.
Other associated proteins
|PF3D7_1121600||parasitophorous vacuole membrane antigen QF 116 exported protein 1 circumsporozoite-related antigen|