Electron micrograph of P. falciparum schizont-infected red blood cells labeled with Mab51-22. Gold labeling is associated with Maurer’s clefts( arrows) and the parasitophorous vacuolar membrane (PVM). b) Saponin-treated infected cell showing slit-like, membranous Maurer’s cleft and electron dense material in the red blood cell cytoplasm labeled with anti-Pf332 Mab 51-22. c) Saponin-treated segmenter reacted with anti-Pf332 Mab 51-22. Gold label is located on the Maurer’s clefts (arrows) in the cytoplasm and in association with the red blood cell membrane. The inset shows a Maurer’s cleft in close association with the erythrocyte membrane.
Hinterberg K, Scherf A, Gysin J, Toyoshima T, Aikawa M, Mazie JC, da Silva LP, Mattei D. Plasmodium falciparum: the Pf332 antigen is secreted from the parasite by a brefeldin A-dependent pathway and is translocated to the erythrocyte membrane via the Maurer's clefts. Exp Parasitol. 1994 79:279-91. Copyright Elsevier 2010.