Transcription sites form a distinct compartment in the nucleus of P. falciparum. Immunofluorescence assay for nascent RNAs of ring stage parasites labeled with BrUTP (BrRNA, green) and the compartments of acetylated H4 (H4ac, active chromatin); a proposed histone marker of nascent transcription (H3K79me3; PfSir2A (silencing compartment); and Nop1 (nucleolar compartment). DNA was labeled by DAPI, in blue. Bars, 1 mm.
Moraes CB, Dorval T, Contreras-Dominguez M, Dossin Fde M, Hansen MA, Genovesio A, Freitas-Junior LH. Transcription sites are developmentally regulated during the asexual cycle of Plasmodium falciparum. PLoS One. 2013;8(2):e55539.
Other associated proteins
|PF3D7_0617900||histone H3 variant|
|PF3D7_1328800||transcriptional regulatory protein sir2a|
|PF3D7_1333700||histone H3-like centromeric protein CSE4|
|PF3D7_1407100||rRNA 2'-O-methyltransferase fibrillarin, putative|