PF3D7_1335300 reticulocyte binding protein 2 homologue b, ALKBH5

Chimeric protein localization and processing. D10-AAA, D10-AAB, D10-ABB and D10-BBB schizonts were methanol-fixed and stained with rabbit anti-PfRh2a or rabbit anti-PfRh2b, mouse anti-PfRhopH3 and DAPI. Images were obtained using deconvolution microscopy. The chimeric proteins from both D10-AAA and D10-AAB localized to the apical organelles (Fig. 3A, left panel) and in close proximity to PfRhopH3 (middle panel). Fluorescence overlays showed some direct colocalization between the PfRh2a/b proteins and PfRhopH3 (right panel). PfRh2a and PfRh2b are known to localize to the rhoptry neck whereas PfRhopH3 localizes to the rhoptry bulb.

Dvorin JD, Bei AK, Coleman BI, Duraisingh MT. Functional diversification between two related Plasmodium falciparum merozoite invasion ligands is determined by changes in the cytoplasmic domain. Mol Microbiol. 2010 75:990-1006.

Other associated proteins

PFID Formal Annotation
PF3D7_0302500 cytoadherence linked asexual protein 3.1
PF3D7_1335400 reticulocyte binding protein 2 homologue a