PF3D7_1416500 NADP-specific glutamate dehydrogenase

Cytosolic localization of GDHa D10 parasites were transfected with pHH1-gdha-GFP and WR99210-resistant parasites were analysed by fluorescence microscopy. GDHa-GFP (panel 1) does not co-localize with the nucleus (Hoechst 33342 staining, panel 2) nor with the mitochondrion (MitoTracker staining, panel 3). From the merged image it is clear that GDHa is a cytosolic protein.

Storm J, Perner J, Aparicio I, Patzewitz EM, Olszewski K, Llinas M, Engel PC, Muller S. Plasmodium falciparum glutamate dehydrogenase a is dispensable and not a drug target during erythrocytic development. Malar J. 2011 Jul 14;10(1):193.