PfSPP localises to the parasite nuclear periphery. IFA of ring, trophozite and schizont stages of PfSPP-HA labeled with anti-PfERC and HA antibodies. Scale bar 1 μm. Co-labeling with ER markers BiP and ER-calcium binding protein (ERC) by IFA showed strong coincidental labeling with PfSPP fluorescence across the entire intra-erythrocytic development of the parasite. SPP is localized to the ER.
Marapana DS, Wilson DW, Zuccala ES, Dekiwadia CD, Beeson JG, Ralph SA, Baum J. Malaria parasite signal peptide peptidase is an ER-resident protease required for growth but not invasion. Traffic. 2012 13(11):1457-65
Other associated proteins
|PF3D7_1108600||endoplasmic reticulum-resident calcium binding protein|
|PF3D7_1457000||signal peptide peptidase|