PfSPP localises to the parasite nuclear periphery.(A) IFA of E64 treated PfSPP-HA schizonts labeled with anti-PfAMA1, PfRON4 and HA antibodies. Scale bar 1 μm. Inset displays magnification of single merozoite. (B) IFA of ring and late schizont stage PfSPP-HA parasites labeled with anti-PfSPP and HA antibodies. Scale bar 1 mm. (C) Immuno-electron micrograph of E64 treated PfSPP-HA schizonts with 12 nm or 18 nm immunogold. Arrowheads mark 12 nm immunogold labels and white asterisks marks parasite apex. Nucleus (Nu), endoplasmic reticulum (ER) and rhoptry (Ro). Scale bar = 200 nm. PfSPP is an ER-resident peptidase that remains intracellular throughout the invasion process.
Marapana DS, Wilson DW, Zuccala ES, Dekiwadia CD, Beeson JG, Ralph SA, Baum J. Malaria parasite signal peptide peptidase is an ER-resident protease required for growth but not invasion. Traffic. 2012 13(11):1457-65
Other associated proteins
|PF3D7_1116000||rhoptry neck protein 4|
|PF3D7_1457000||signal peptide peptidase|