Protein accumulates at sites marked by PTEX during native PEXEL-dependent protein export. Widefield deconvolution microscopy of parasites fixed and labelled by IFA for EXP2 (green), the nucleus (40,6–diamidino-2-phenylindole (DAPI), blue) and (a) PfEMP3 (red), a protein exported by PEXEL-dependent processes, or (b) PfEMP1, a protein likely to undergo PEXEL-independent export, showed some areas of possible association of both exported proteins and EXP2; however, results were inconclusive. Parasite ages are as shown. Scale bars, 1 mm. Parasites were labelled by IFA for EXP2 (green), RESA (red) and the nucleus (DAPI, blue) having been (c) fixed o12 min or 60–90 min after invasion and imaged by widefield deconvolution microscopy (scale bar, 1 mm).
Riglar DT, Rogers KL, Hanssen E, Turnbull L, Bullen HE, Charnaud SC, Przyborski J, Gilson PR, Whitchurch CB, Crabb BS, Baum J, Cowman AF. Spatial association with PTEX complexes defines regions for effector export into Plasmodium falciparum-infected erythrocytes. Nat Commun. 2013 Jan 29;4:1415.
Other associated proteins
|PF3D7_0102200||ring-infected erythrocyte surface antigen|
|PF3D7_0201900||erythrocyte membrane protein 3|