KAHRP chimaeras localise to the endoplasmic reticulum in addition to the parasitophorous vacuole or erythrocyte cytosol. Images captured by immunofluorescence microscopy show substantial colocalisation of KAHRP chimaeras with the endoplasmic reticulum calcium-binding protein ERC (upper panel). Intraparasitic fluorescence is also evident when chimaeras were colocalised with the parasitophorous vacuole membrane protein EXP-2 PF14_0678 (lower panel). Only the wild type (WT) PEXEL chimaera efficiently exported to the erythrocyte cytosol,
Boddey JA, Moritz RL, Simpson RJ, Cowman AF. Role of the Plasmodium export element in trafficking parasite proteins to the infected erythrocyte. Traffic. 2009 10:285-99. Copyright John Wiley & Sons Ltd. 2010.
Other associated proteins
|PF3D7_1108600||endoplasmic reticulum-resident calcium binding protein|