PF3D7_0207600 serine repeat antigen 5

SERA6 is a soluble parasitophorous vacuole (PV) protein which may partially interact with the PVM. Upper panel: IFA demonstrates colocalization of the anti-SERA6 and anti-SERA5 signal in mature schizonts, except that the SERA6 signal additionally shows an association with the outer confines of the intracellular parasite, probably corresponding to the PVM. Scale bar, 5 μm. Lower panel: Immuno-electron microscopic localization of SERA6 in a P. falciparum schizont, using the anti-S6C1 antibodies labelled with 10 nm immunogold. The majority of the signal is clearly associated with the peripheral space between intracellular merozoites, consistent with a PV localization. Magnification, x 15000.

Ruecker A, Shea M, Hackett F, Suarez C, Hirst EM, Milutinovic K, Withers-Martinez C, Blackman MJ. Proteolytic activation of the essential parasitophorous vacuole cysteine protease SERA6 accompanies malaria parasite egress from its host erythrocyte. J Biol Chem. 2012287(45):37949-63.

Other associated proteins

PFID Formal Annotation
PF3D7_0207500 serine repeat antigen 6
PF3D7_0620400 merozoite surface protein 10
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